Craig Mack died at his home in Walterboro, about 50 miles west of Charleston. Coroners say it looked as though Mack died of natural causes.
Mack's debut 1994 single, Flava In Ya Ear, which featured verses from a then-unknown Notorious B.I.G. as well as Rampage, LL Cool J and Busta Rhymes, was one of the first "posse cuts" (a collaboration between four or more artists) to achieve mainstream success, reaching No. 9 on the Billboard Hot 100 and receiving a Grammy nomination for best rap solo performance.